瑞禧生物货号：Ruixi-A225100
化学名称：Adaptaquin
同义名称：7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
CAS号：385786-48-1
分子式：C₂₁H₁₆ClN₃O₂
分子量：377.82
产品类别：Research Tools; Standards; Molecular Biology; Neurochemicals; Pharmaceutical/API Drug Impurities/Metabolites;
产品应用：General Uses:Ischemic injury Research, Renal anemia, HIF Prolyl Hydroxylase Inhibitor, Antioxidant, NeuroprotectiveDescription:Adaptaquin inhibits the HIF PHDs in brain in a dose dependent fashion and penetrates blood brain barrier (BBB). Exhibited functional recovery in intra-cerebral hemorrhage rat model; inhibits ATF4 gene. Potent HIF PHD inhibitor (hypoxia inducible factor), Selective PDH2 inhibitor.This compound is suitable for pyruvate dehydrogenase (PDH) related research.
参考文献：1. Yang Y, et al. 2016. Transl Stroke Res. ; 7(6): 535–547.
2. Vaithinathan S, et al. 2016; Antioxid Redox Signal. 2014 Jun 1; 20(16): 2631–2665.
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