Name:Temozolomide (CCRG 81045)
Synonyms:NSC 362856,TMZ,CCRG 81045,Methazolastone,Temodar,Temodal
CAS Number:85622-93-1
Formula:C6H6N6O2
M.w.:194.15
DMSO (mg/mL)Max Solubility:38
DMSO (mM)Max Solubility:195.72
Form:free base
SMILES:CN1N=NC2=C(N=C[N]2C1=O)C(N)=O
ALogP:0.052
Target:Apoptosis related,Autophagy,DNA/RNA Synthesis
Pathway:DNA Damage/DNA Repair
Information:Temozolomide (NSC 362856,TMZ,CCRG 81045,Methazolastone,Temodar,Temodal) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity.
瑞禧生物是您专业的小分子合成定制合作伙伴。我们专注于为医药研发、材料科学及学术研究提供从毫克到公斤级的一站式合成解决方案。无论是常规分子、复杂手性化合物、同位素标记物还是特定杂质，我们的资深团队都能凭借先进技术平台高效完成。我们始终坚持严格的质量控制，确保产品纯度与结构准确，并恪守保密承诺。选择瑞禧生物，就是选择可靠与精准，让我们以卓越的合成能力，加速您的创新突破。欢迎垂询，定制您的专属分子。