Name:Decitabine (NSC 127716)
Synonyms:Deoxycytidine, Dacogen, 5-aza-2'-deoxycytidine, 5-AZA-dC, 5-aza-CdR,NSC 127716
CAS Number:2353-33-5
Formula:C8H12N4O4
M.w.:228.21
DMSO (mg/mL)Max Solubility:45
DMSO (mM)Max Solubility:197.19
Form:free base
SMILES:NC1=NC(=O)N(C=N1)C2CC(O)C(CO)O2
ALogP:-1.093
Target:Apoptosis related,DNA Methyltransferase,Nucleoside Analog/Antimetabolite
Pathway:Epigenetics
Information:Decitabine (Deoxycytidine, Dacogen, 5-aza-2'-deoxycytidine, 5-AZA-dC, 5-aza-CdR,NSC 127716) is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.
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