Name:Zoledronic acid (ZOL 446)
Synonyms:ZA, Zoledronate, CGP-4244, GP42446A, ZOL 446, Zometa, Zomera, Aclasta, Reclast
CAS Number:118072-93-8
Formula:C5H10N2O7P2
M.w.:272.09
DMSO (mg/mL)Max Solubility:<1
DMSO (mM)Max Solubility:N/A
Form:Free Base
SMILES:OC(C[N]1C=CN=C1)([P](O)(O)=O)[P](O)(O)=O
ALogP:-1.209
Target:Apoptosis related,Autophagy,Ras,Rho
Pathway:Cell Cycle
Information:Zoledronic acid (ZA, Zoledronate, CGP-4244, GP42446A, ZOL 446, Zometa, Zomera, Aclasta, Reclast), a potent osteoclast inhibitor, induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho. Zoledronic acid (ZA) also induces autophagy.
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