Name:Gemigliptin
Synonyms:Zemiglo, LC15-0444
CAS Number:911637-19-9
Formula:C18H19F8N5O2
M.w.:489.36
DMSO (mg/mL)Max Solubility:98
DMSO (mM)Max Solubility:200.26
Form:Free Base
SMILES:NC(CN1CC(F)(F)CCC1=O)CC(=O)N2CCC3=C(C2)N=C(N=C3C(F)(F)F)C(F)(F)F
ALogP:1.29
Target:DPP
Pathway:Proteases
Information:Gemigliptin (Zemiglo, LC15-0444) is a potent, selective and long-acting dipeptidyl peptidase 4 (DPP 4) inhibitor with a Ki of 7.25 nM. Gemigliptin shows at least >23,000-fold selectivity for DPP-4 over various proteases and peptidases, including DPP-8, DPP-9, and fibroblast activation protein (FAP)-α.
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