Name:Simufilam dihydrochloride
Synonyms:PTI-125 dihydrochloride
CAS Number:2480226-06-8
Formula:C15H23Cl2N3O
M.w.:332.27
DMSO (mg/mL)Max Solubility:66
DMSO (mM)Max Solubility:198.63
Form:Dihydrochloride
SMILES:Cl.Cl.CN1CCC2(CC1)NCC(=O)N2CC3=CC=CC=C3
ALogP:1.86
Target:Actin
Pathway:Cytoskeletal Signaling
Information:Simufilam (PTI-125) Dihydrochloride is a small molecule modulator that preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
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