Name:Apilimod (STA-5326) mesylate
Synonyms:STA-5326 mesylate
CAS Number:870087-36-8
Formula:C25H34N6O8S2
M.w.:610.7
DMSO (mg/mL)Max Solubility:60
DMSO (mM)Max Solubility:98.25
Form:mesylate
SMILES:CC1=CC(=CC=C1)/C=N/NC2=CC(=NC(=N2)OCCC3=CC=CC=N3)N4CCOCC4.C[S](O)(=O)=O.C[S](O)(=O)=O
ALogP:3.657
Target:Interleukins,PIKfyve
Pathway:Immunology & Inflammation
Information:Apilimod (STA-5326) mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod mesylate (STA-5326 mesylate) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.
瑞禧生物是您专业的小分子合成定制合作伙伴。我们专注于为医药研发、材料科学及学术研究提供从毫克到公斤级的一站式合成解决方案。无论是常规分子、复杂手性化合物、同位素标记物还是特定杂质，我们的资深团队都能凭借先进技术平台高效完成。我们始终坚持严格的质量控制，确保产品纯度与结构准确，并恪守保密承诺。选择瑞禧生物，就是选择可靠与精准，让我们以卓越的合成能力，加速您的创新突破。欢迎垂询，定制您的专属分子。