Name:Alobresib (GS-5829)
Synonyms:N/A
CAS Number:1637771-14-2
Formula:C26H23N5O2
M.w.:437.49
DMSO (mg/mL)Max Solubility:87
DMSO (mM)Max Solubility:198.86
Form:Free Base
SMILES:CC1=C(C(=NO1)C)C2=CC(=C3N=C([NH]C3=C2)C4CC4)C(O)(C5=CC=CC=N5)C6=CC=CC=N6
ALogP:3.767
Target:Akt,Apoptosis related,Epigenetic Reader Domain,ERK,Myc,NF-κB
Pathway:Epigenetics
Information:Alobresib (GS-5829) is a novel BET inhibitor that represents a highly effective therapeutics agent against recurrent/chemotherapy-resistant USC-overexpressing c-Myc. Alobresib (GS-5829) inhibits CLL cell proliferation and induces leukemia cell apoptosis through deregulation of key signaling pathways, such as BLK, AKT, ERK1/2, and MYC. Alobresib (GS-5829) also inhibits NF-κB signaling.
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