Name:Troglitazone (CS-045)
Synonyms:Rezulin, Romglizone, Prelay, Romozin
CAS Number:97322-87-7
Formula:C24H27NO5S
M.w.:441.54
DMSO (mg/mL)Max Solubility:88
DMSO (mM)Max Solubility:199.3
Form:free base
SMILES:CC1=C(O)C(=C2CCC(C)(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)OC2=C1C)C
ALogP:5.682
Target:Apoptosis related,Autophagy,Ferroptosis,PPAR
Pathway:Metabolism
Information:Troglitazone (Rezulin, Romglizone, Prelay, CS045, Romozin) is a potent agonist for the peroxisome proliferator-activated receptor-(PPAR) that is a ligand activated transcription factor regulating cell differentiation and growth. Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells. Troglitazone prevents RSL3-induced ferroptosis and lipid peroxidation in Pfa1 cells.
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