Name:T0901317
Synonyms:N/A
CAS Number:293754-55-9
Formula:C17H12F9NO3S
M.w.:481.33
DMSO (mg/mL)Max Solubility:96
DMSO (mM)Max Solubility:199.45
Form:free base
SMILES:OC(C1=CC=C(C=C1)N(CC(F)(F)F)[S](=O)(=O)C2=CC=CC=C2)(C(F)(F)F)C(F)(F)F
ALogP:4.826
Target:Apoptosis related,FXR,Liver X Receptor,ROR
Pathway:Metabolism
Information:T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of 20nM for LXRα and 5 μM for FXR, respectively. T0901317 is a dual inverse agonist of RORα and RORγ with Ki of 132 nM and 51 nM, respectively. T0901317 significantly suppresses cell proliferation and induces apoptosis.
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