Name:Rosiglitazone (BRL-49653) maleate
Synonyms:BRL-49653C
CAS Number:155141-29-0
Formula:C18H19N3O3S.C4H4O4
M.w.:473.5
DMSO (mg/mL)Max Solubility:94
DMSO (mM)Max Solubility:198.52
Form:Maleate
SMILES:CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C3=NC=CC=C3.OC(=O)\C=C/C(O)=O
ALogP:3.307
Target:Autophagy,Ferroptosis,PPAR,TRP Channel
Pathway:Metabolism
Information:Rosiglitazone maleate (BRL-49653C), a member of the thiazolidinedione class of antihyperglycaemic agents, is a high-affinity selective agonist of the peroxisome proliferator-activated receptor-γ (PPAR-γ) with IC50 of 42 nM. Rosiglitazone maleate also modulates TRP channels and induces autophagy. Rosiglitazone prevents ferroptosis.
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