Name:Gossypol
Synonyms:BL 193
CAS Number:303-45-7
Formula:C30H30O8
M.w.:518.55
DMSO (mg/mL)Max Solubility:100
DMSO (mM)Max Solubility:192.85
Form:free base
SMILES:CC(C)C1=C(O)C(=C(C=O)C2=C1C=C(C)C(=C2O)C3=C(O)C4=C(C=C3C)C(=C(O)C(=C4C=O)O)C(C)C)O
ALogP:6.592
Target:Apoptosis related,Bcl-2,Dehydrogenase
Pathway:Apoptosis
Information:Gossypol (BL 193) is an orally-active polyphenol isolated from cotton seeds and roots. Gossypol is a potent inhibitor of 5α-reductase 1 and 3α-hydroxysteroid dehydrogenase with IC50 of 3.33 μM and 0.52 μM in cell-free assay, respectively. Gossypol also inhibits the binding of BH3 peptide to Bcl protein with IC50 of 0.4 μM and 10 μM for Bcl-XL and Bcl-2, respectively. Gossypol induces apoptosis and cell growth inhibition in various cancer cells.
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