瑞禧生物货号:Ruixi-C982154
化学名称:N-(2-Cyanoethyl)-N-[(1,1-dimethylethoxy)carbonyl]-β-Alanine Ethyl Ester
同义名称:Ethyl 3-((tert-Butoxycarbonyl)(2-isocyanoethyl)amino)propanoate
CAS号:266353-22-4
分子式:C₁₃H₂₂N₂O₄
分子量:270.32
产品类别:Building Blocks; Miscellaneous;
产品应用:N-(2-Cyanoethyl)-N-[(1,1-dimethylethoxy)carbonyl]-β-Alanine Ethyl Ester is an intermediate in the synthesis of GNE-781 (D447825), a derivative of a highly advanced, potent and selective bromodomain inhibitor of cyclic adenosine monophosphate response element binding protein (CBP). Inhibition of the bromodomain of the transcriptional regulator CBP/P300 is an especially interesting new therapeutic approach in oncology.
参考文献:Romero, F.A.; et al.: J. Med. Chem, DOI: 10.1021/acs.jmedchem.7b00796 (2017)
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