产品货号：C374215
化学名称：2-chloro-1-(4-methylphenyl)ethanone
同义名称：2-Chloro-4'-methylacetophenone;2-Chloro-1-(4-methylphenyl)ethan-1-one;2-Chloro-1-(4'-methylphenyl)ethanone;2-Chloro-1-(p-tolyl)ethanone;2-Chloro-4'-methylacetophenone;4-(2-Chloroacetyl)toluene;4-Methylphenacyl Chloride;Chloromethyl 4-Methylphenyl Ketone;Chloromethyl p-Tolyl Ketone;NSC 41667;p-Methyl-2-chloroacetophenone;p-Methylphenacyl Chloride;α-Chloro-4'-methylacetophenone
CAS号：4209-24-9
分子式：C₉H₉OCl
分子量：168.62
产品类别：Building Blocks; Miscellaneous;
产品应用：2-chloro-1-(4-methylphenyl)ethanone (cas# 4209-24-9) can be used for preparation of acetophenone derivatives, which are known to be fungicides that control phytopathogenic fungi. In addition, this compound can be used for synthesis of clinafloxacin triazole hybrids, which are also known for the their antifungal and antibacterial activity. Moreover, this compound was found to inhibit (uncompetitively to ATP) pyruvate dehydrogenase (PDH), meaning it inhibits further glucose oxidation. That is why this compound can potentially be used to treat such conditions as diabetes and/or ischemia.
参考文献：Dan, W., et al.: Bioorg. Med. Chem. Lett., 28, 2861 (2018); Wang, Y., et al.: Bioorg. Med. Chem. Lett., 22, 5363 (2012); Espinal, J., et al.: Drug Dev. Res., 35, 130 (1995).
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