Folic acid-PEG-NHS,FA-PEG-NHS
作者:Folic acid-PEG-NHS,FA-PEG-NHS 发布时间:2022-08-01 09:05:19
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Folic
acid-PEG-NHS,FA-PEG-NHS
NHS (polyethylene glycol) folic acid
Synonym: Folate PEG
NHS, NHS PEG Folate, NHS PEG Folic acid
Product
Structure:
Product
Specifications:
l Catalog Numbers:PS2-HFA-1K,2K,3.4K,5K,10K.
l Appearance: Orange/yellow
to brownish solid.
l Solubility:
DMSO.
l Stability: 1 Years at-20°C, Desiccate.
Protect from light.
l CAS
Number:-
l Molecular
Weight(PEG): 1K,2K,3.4K,5K,10K.
l Reactive
group: NHS.
Description:
FA-PEG-NHS is one of
ruixibio amine reactive folate PEG derivatives that have a folic acid on one
terminus of PEG chain and a succinimidyl NHS group on the other PEG end. Folic
acid is also known as vitamin M, vitamin B9 or pteroyl-L-glutamic acid. Folic
acid is an essential bioactive molecule for numerous biological functions. It participates
in the synthesis, repairing and methylation of DNA as well as to act as a
cofactor in many biological reactions. NHS functionalized folic acid PEG
enables attachment of folic acid to amine groups from other molecules or
materials quickly and efficiently. NHS reacts with primary amine group at
elevated pH to form a stable amide bond. Flexible PEG chain between NHS and
folate offers better water solubility, less steric hindrance and higher
stability. Molecules or materials conjugated with PEG folic acid are useful for
targeted drug delivery, cellular imaging and bioassay development.
Handling
and Use:
FA-PEG-NHS is sensitive to light and temperature. For
best use, material should always be kept in low temperature in dry condition.
Protect from light.
Avoid frequent thaw and freezing. For more
information about using this product, .
Storage
Conditions:
FA-PEG-NHS should be
stored at -20℃.
Desiccate. Protect from light. Materials may be handled under inert gas for
best stability.
References:
l Acta
Biomaterialia------ Folic acid modified
cell membrane capsules encapsulated doxorubicin and indocyanine green for
highly effective combinational therapy in vivo.
l Sensors
and Actuators B: Chemical------ Affordable
and simple method for separating and detecting ovarian cancer circulating tumor
cells using BSA coated magnetic nanoprobes modified with folic acid.
l Nanoscale
Research Letters------ Tumor-Targeted and
Biocompatible MoSe2 Nanodots@Albumin Nanospheres as a Dual-Modality Therapy
Agent for Synergistic Photothermal Radiotherapy.
Related
Products:
FA-PEG-COOH, FA-PEG-FITC
FA-PEG-Maleimide ,FA-PEG-SH
FA-PEG-NH2,DSPE-PEG-FA
This
product is for research use only and is not intended for use in humans or for
diagnostic use.