Biotin-PEG5-azide
作者:Biotin-PEG5-azide 发布时间:2022-09-19 15:28:51
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Chemical Formula: C22H33N7O9
Molecular Weight: 539.54
CAS: N/A
Purity: >95%
Physical Form: oil
Solubility: MeOH, DMF and DMSO
Storage at: -20 oC
PTAD-PEG4-azide is a heterobifunctional linker containing a PTAD moiety for tyrosine click reaction and an azide for click chemistry.
4-Phenyl-3H-1,2,4-triazoline-3,5(4H)-diones (PTADs) is a recently reported bioorthogonal probe that is capable of click reactions with tyrosine. Their benefits include but not limited to:
Demonstrated selectivity against tyrosine over cysteine and lysine.
Chemoselective for the phenolic side chain of tyrosine residues in modification of small molecules, peptides, and proteins
Applicable in a wide variety of biologically acceptable aqueous buffers over a broad range of pH without using heavy metal catalysts.
The tyrosine click linkage offers better stability than maleimide to temperature, extremes of pH, and exposure to human blood plasma.