Chemical Formula: C20H18N2O2
Molecular Weight: 318.37
CAS: 1644038-97-0
Purity: >95%
Physical Form: solid
Solubility: DCM, acetonitrile, DMF and DMSO
Storage at: -80 oC
APN-BCN is a heterobifunctional linker containing a APN moiety with exquisite chemoselectivity for cysteine and a BCN moiety for click chemistry. The superior stability of APN-cysteine conjugates in aqueous media, human plasma, and living cells makes this new thiol-click reaction a promising methodology for applications in bioconjugation.
The BCN moiety has high specific reactivity toward azide group through strain-promoted click reaction in the absence of a catalyst.
Excellent biocompatibility – strain-promoted click reaction occurs rapidly under mild buffer conditions with no need of accessory toxic copper catalyst
High chemoselectivity – azides and BCN groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency