Chemical Formula: C39H40N4O7
Molecular Weight: 676.76
CAS: N/A
Purity: >90%
Physical Form: oil
Solubility: DCM, acetonitrile, DMF and DMSO
Storage at: -20 oC
DBCO-PEG4-APN is a heterobifunctional linker containing a APN moiety with exquisite chemoselectivity for cysteine and a DBCO moiety for click chemistry. The superior stability of APN-cysteine conjugates in aqueous media, human plasma, and living cells makes this new thiol-click reaction a promising methodology for applications in bioconjugation.
The dibenzocyclooctyne group (DBCO) is thermally stable with high specific reactivity toward azide group through strain-promoted click reaction in the absence of a catalyst.
Excellent biocompatibility – strain-promoted click reaction occurs rapidly under mild buffer conditions with no need of accessory toxic copper catalyst
High chemoselectivity – azides and DBCO groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency
Hydrophilic PEG4 Spacer – reduces aggregation, minimizes steric hindrance, and enhances solubility