Chemical Formula: C31H29N3O4S2
Molecular Weight: 571.71
CAS: N/A
Purity: >90%
Physical Form: white foam
Solubility: DCM, THF, acetonitrile, DMF and DMSO
Storage at: -20 oC
DBCO-SS-aldehyde is a cleavable heterobifunctional linker containing a DBCO moiety for click chemistry and an aldehyde group for oxime/hydrazone ligation. The dibenzocyclooctyne group (DBCO) is thermally stable with high specific reactivity toward azide group through strain-promoted click reaction in the absence of a catalyst. The ligation reaction is very fast and results in almost quantitative yield of stable triazoles. Within physiological temperature and pH ranges, the DBCO group does not react with amines or hydroxyls, which are naturally present in many biomolecules. Thus, DBCO has found broad application for studying dynamic biological systems such as live cells, whole organisms, and liv animals, ranging from visualizing protein expression, tracking protein localization, measuring protein activity and turnover, to nucleic acid immobilization and tracking, and lipid labeling in living cells and live animals.
Excellent biocompatibility – strain-promoted click reaction occurs rapidly under mild buffer conditions with no need of accessory toxic copper catalyst
High chemoselectivity – azides and DBCO groups do not react or interfere with other functional groups found in biological samples but conjugate to one another with high efficiency
Cleavable SS bond – can be cleaved with DTT, GSH or TCEP