DSPE-PEG-Folate,DSPE-PEG-FA
作者:DSPE-PEG-Folate,DSPE-PEG-FA 发布时间:2022-08-01 09:05:19
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DSPE-PEG-Folate,DSPE-PEG-FA
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene
glycol)]
Synonym: DSPE PEG
Folate, Folic acid PEG DSPE
Product
Structure:
Product
Specifications:
l Catalog
Numbers:PS2-DEFA-1K,2K,3K,5K,10K.
l Appearance:Yellow,
orange to brownish solid.
l Solubility:>5
mg/mL in hot water, chloroform/methanol, and DMSO.
l Stability: 1 Years at-20°C, Desiccate.
Protect from light.
l CAS
Number:1236288-25-7
l Molecular
Weight(PEG):1K,2K,3.4K,5K,10K
Description:
DSPE
PEG Folate, also called Folic acid PEG DSPE, is one of functional phospholipid
PEG products provided by ruixibio for targeted drug delivery, nanoparticle
functionalization, liposome formation as well as many other
applications.Pegylated phospholipid products demonstrate excellent amphilphilic
properties and offer superior advantages for small and large molecule targted
delivery. DSPE (1,2-distearoyl-sn-glycero-3-phosphophoethanolamine) PEG folic
acid is a C18 phospholipid PEG derivative which can be used for folate receptor
targeting. Folic acid is also known as vitamin M, vitamin B9 or
pteroyl-L-glutamic acid. Folic acid is an essential bioactive molecule for
numerous biological functions. It participates in the synthesis, repairing and
methylation of DNA as well as to act as a cofactor in many biological
reactions.Pegylated DSPE and Folic acid is soluble both in organic solvents and
aqueous buffer. They have been used for preparing folate receptor targeting
liposome for either small molecules or large molecules delivery. Pegylation of
phospholipids significantly improves the blood circulation time and stability
for encapsulated drugs; it also suppresses the non-specific binding of charged
molecules to the modified surfaces.
Handling
and Use:
DSPE-PEG-FA should
always be kept in low temperature in dry condition. Prepare fresh solution
right before use.
Avoid frequent thaw
and freezing. For more information about using this product, .
Related
Products:
DSPE-PEG-NH2,
DSPE-PEG-COOH
DSPE-PEG-NHS
,DSPE-PEG-FA
DSPE-PEG-SH,DSPE-PEG-MAL
References:
l Bubble-generating
nano-lipid carriers for ultrasound/CT imaging-guided efficient tumor therapy------ International
Journal of Pharmaceutics(IF=3.862)
l Nasopharyngeal
cancer combination chemoradiation therapy based on folic acid modified,
gefitinib and yttrium 90 co-loaded, core-shell structured lipid-polymer hybrid
nanoparticles------ Biomedicine & Pharmacotherapy(IF=3.457)
l Targeted
delivery of in situ PCR-amplified Sleeping Beauty transposon genes to cancer
cells with lipid-based nanoparticle-like protocells------ Biomaterials(IF=10.273)
l Cancer
cell targeting, controlled drug release and intracellular fate of biomimetic
membrane-encapsulated drug-loaded nano-graphene oxide nanohybrids------ Journal
of Materials Chemistry B(IF=4.776)
l In vitro
and in vivo evaluation of folate-mediated PEGylated nanostructured lipid
carriers for the efficient delivery of furanodiene.
l NIR
stimulus-responsive core–shell type nanoparticles based on photothermal
conversion for enhanced antitumor efficacy through chemo-photothermal therapy------ Nanotechnology(IF=3.404)
l lipid
nanobubbles as an ultrasound-triggered artesunate delivery system for
imaging-guided,tumor-targeted chemotherapy.
l Facile
synthesis of biocompatible MoSe2 nanoparticles for efficient
targeted photothermal therapy of human lung cancer------ RSC
Advances(IF=2.963)
l Inhalable
dry powder prepared from folic acid-conjugated Docetaxel liposomes alters
pharmacodynamic and pharmacokinetic properties relevant to lung cancer
chemotherapy.
l Near
infrared radiated stimulus-responsive liposomes based on photothermal
conversion as drug carriers for co-delivery of CJM126 and cisplatin------ Materials
Science and Engineering C(IF=5.08)
l Normalizing
Tumor Microenvironment Based on Photosynthetic Abiotic/Biotic Nanoparticles------ ACS
Nano(13.709)
l A novel
near-infrared triggered dual-targeted nanoplatform for mitochondrial combined
photothermal-chemotherapy of cancer in vitro------ Nanotechnology(3.404)
l Folate-decorated
and NIR-triggered nanoparticles loaded with platinum(IV)-prodrug plus
5-fluorouracil for targeted and chemo-photothermal combination therapy.
l Paclitaxel
prodrug based mixed micelles for tumor-targeted chemotherapy------ RSC
Advances(IF=2.963)
This
product is for research use only and is not intended for use in humans or for diagnostic
use.